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FKBP12 PROTAC RC32

CAS No. 2375555-66-9

FKBP12 PROTAC RC32( —— )

Catalog No. M33217 CAS No. 2375555-66-9

FKBP12 PROTAC RC32 is a PROTAC-like degrader targeting FKBP12. It can degrade FKBP12 in organs after intraperitoneal administration.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    FKBP12 PROTAC RC32
  • Note
    Research use only, not for human use.
  • Brief Description
    FKBP12 PROTAC RC32 is a PROTAC-like degrader targeting FKBP12. It can degrade FKBP12 in organs after intraperitoneal administration.
  • Description
    FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology. FKBP12 PROTAC RC32 contains conjugation of Rapamycin (HY-10219) and a ligand for an Cereblon E3 ubiquitin ligase (Pomalidomide; HY-10984).
  • In Vitro
    Western Blot Analysis Cell Line:Jurkat cells Concentration:0.1, 1, 10, 100, 1000 nM Incubation Time:For 12?hours Result:Resulted in 50% protein degradation (DC50) of ~0.3?nM after only 12?h of treatment.
  • In Vivo
    Animal Model:Male and female mice Dosage:30?mg/kg Administration:IP; twice a day; 1 day Result:Degraded the FKBP12 protein in most of the organs of treated mice after only 1 day of treatment.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PROTACs
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2375555-66-9
  • Formula Weight
    1426.69
  • Molecular Formula
    C75H107N7O20
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 10 mg/mL (7.01 mM; Ultrasonic )
  • SMILES
    O=C1NC(C(N2C(C(C=CC=C3NCCOCCOCCN4C=C(COCCO[C@H]5CC[C@@H](C[C@H]([C@](OC([C@@]6([H])N(C(C([C@]7(O)O[C@@]8([H])CC[C@H]7C)=O)=O)CCCC6)=O)([H])CC([C@@H](/C=C(C)\[C@@H](O)[C@@H](OC)C([C@H](C)C[C@H](C)/C=C\C=C\C=C(C)/[C@@H](OC)C8)=O)C)=O)C)C[C@H]5OC)N=N4)=C3C2=O)=O)CC1)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. A chemical approach for global protein knockdown from mice to non-human primates. Cell Discov. 2019 Feb 5;5:10.?
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